Skeletal muscle mTORC1 regulates neuromuscular junction stability
نویسندگان
چکیده
منابع مشابه
Muscle-derived collagen XIII regulates maturation of the skeletal neuromuscular junction.
Formation, maturation, stabilization, and functional efficacy of the neuromuscular junction (NMJ) are orchestrated by transsynaptic and autocrine signals embedded within the synaptic cleft. Here, we demonstrate that collagen XIII, a nonfibrillar transmembrane collagen, is another such signal. We show that collagen XIII is expressed by muscle and its ectodomain can be proteolytically shed into t...
متن کاملNeurotransmission regulates stability of acetylcholine receptors at the neuromuscular junction.
The majority of acetylcholine receptors (AChRs) at normally innervated neuromuscular junctions are stable, with a half-life averaging about 12 d in most rodent muscles. Following denervation, the AChRs turn over much more rapidly after a lag period. The mechanism by which motor nerves normally maintain stabilization of junctional AChRs is not yet known. In order to determine whether synaptic tr...
متن کاملAMPD1 regulates mTORC1-p70 S6 kinase axis in the control of insulin sensitivity in skeletal muscle
BACKGROUND Insulin resistance triggered by excess fat is a key pathogenic factor that promotes type 2 diabetes. Understanding molecular mechanisms of insulin resistance may lead to the identification of a novel therapeutic target for type 2 diabetes. AMPD1, an isoform of AMP deaminase (AMPD), is suggested to play roles in the regulation of glucose metabolism through controlling AMP-activated pr...
متن کاملLoss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration
Neuromuscular junction degeneration is a prominent aspect of sarcopenia, the age-associated loss of skeletal muscle integrity. Previously, we showed that muscle stem cells activate and contribute to mouse neuromuscular junction regeneration in response to denervation (Liu et al., 2015). Here, we examined gene expression profiles and neuromuscular junction integrity in aged mouse muscles, and un...
متن کاملGastrocnemius Skeletal Muscle Microvasculature and Neuromuscular Junction Alterations in Mice with Experimental Acute Chagas Infection
A light and transmission electron microscopy study was performed in skeletal muscles (SM) Gastrocnemius (G) from mice experimentally infected with Trypanosoma cruzi to determine changes on microvessels (MV) and neuromuscular junction (NMJ) of G. In this study 10 male (mus musculus) (20 g) were infected subcutaneally with 1.10 bloodstream trypomastigotes M/DID/Ve/02/DSM strain. Five mice were ke...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cachexia, Sarcopenia and Muscle
سال: 2019
ISSN: 2190-5991,2190-6009
DOI: 10.1002/jcsm.12496